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The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation
MEKK1 is a mitogen activated protein kinase kinase kinase (MAP3K) that regulates MAPK activation, and is the only known mammalian kinase that is also a ubiquitin ligase. MEKK1 contains a RING domain within its amino-terminal regulatory region, and MEKK1 has been shown to ubiquitylate the AP-1 transc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653270/ https://ncbi.nlm.nih.gov/pubmed/22582703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120406 |
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