Coupling Deep Transcriptome Analysis with Untargeted Metabolic Profiling in Ophiorrhiza pumila to Further the Understanding of the Biosynthesis of the Anti-Cancer Alkaloid Camptothecin and Anthraquinones

The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as anthraquinones that are derived from the combination of the isochorismate and hemiterpenoid pathways. The biosynthesis of these secondary pro...

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Hauptverfasser: Yamazaki, Mami, Mochida, Keiichi, Asano, Takashi, Nakabayashi, Ryo, Chiba, Motoaki, Udomson, Nirin, Yamazaki, Yasuyo, Goodenowe, Dayan B., Sankawa, Ushio, Yoshida, Takuhiro, Toyoda, Atsushi, Totoki, Yasushi, Sakaki, Yoshiyuki, Góngora-Castillo, Elsa, Buell, C. Robin, Sakurai, Tetsuya, Saito, Kazuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Special Issue – Regular Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653139/
https://ncbi.nlm.nih.gov/pubmed/23503598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/pcp/pct040
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