Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia

Acute stress reduces pain sensitivity by engaging an endocannabinoid signaling circuit in the midbrain. The neural mechanisms governing this process and molecular identity of the endocannabinoid substance(s) involved are unknown. We combined behavior, pharmacology, immunohistochemistry, RNA interfer...

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Main Authors: Gregg, Laura C., Jung, Kwang-Mook, Spradley, Jessica M., Nyilas, Rita, Suplita, Richard L., Zimmer, Andreas, Watanabe, Masahiko, Mackie, Ken, Katona, István, Piomelli, Daniele, Hohmann, Andrea G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652685/
https://ncbi.nlm.nih.gov/pubmed/22787031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0013-12.2012
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