Lmo2 induces hematopoietic stem cell like features in T-cell progenitor cells prior to leukemia

LIM domain Only 2 (Lmo2) is frequently deregulated in sporadic and gene therapy-induced acute T-cell lymphoblastic leukemia (T-ALL) where its overexpression is an important initiating mutational event. In transgenic and retroviral mouse models, Lmo2 expression can be enforced in multiple hematopoiet...

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Autores principales: Cleveland, Susan M., Smith, Stephen, Tripathi, Rati, Mathias, Elizabeth M., Goodings, Charnise, Elliott, Natalina, Peng, Dunfa, El-Rifai, Wael, Yi, Dajun, Chen, Xi, Li, Liqi, Mullighan, Charles, Downing, James R., Love, Paul, Davé, Utpal P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652616/
https://ncbi.nlm.nih.gov/pubmed/23378057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1345
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