Lin28a regulates germ cell pool size and fertility

Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reprod...

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Main Authors: Shinoda, Gen, de Soysa, T. Yvanka, Seligson, Marc T., Yabuuchi, Akiko, Fujiwara, Yuko, Huang, Pei Yi, Hagan, John P., Gregory, Richard I., Moss, Eric G., Daley, George Q.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652309/
https://ncbi.nlm.nih.gov/pubmed/23378032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1343
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