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The heparanase/syndecan-1 axis in cancer: mechanisms and therapies
Heparanase is an endoglucuronidase that cleaves heparan sulfate chains of proteoglycans. In many malignancies, high heparanase expression and activity correlate with an aggressive tumor phenotype. A major consequence of heparanase action in cancer is a robust up-regulation of growth factor expressio...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651779/ https://ncbi.nlm.nih.gov/pubmed/23374281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12168 |
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