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Endorepellin LG1/2 domains bind Ig3-5 of VEGFR2 and block proangiogenic signaling by VEGFA in endothelial cells
Endorepellin, a processed fragment of perlecan protein core, possesses anti-angiogenic activity by antagonizing endothelial cells. Endorepellin contains three laminin G-like (LG) domains and binds simultaneously to vascular endothelial growth factor receptor 2 (VEGFR2) and α2β1 integrin, resulting i...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651768/ https://ncbi.nlm.nih.gov/pubmed/23374253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12164 |
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