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Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry

Angiotensin-converting enzyme 2 (ACE2) catalyzes conversion of ANG II to ANG-(1–7). The present study uses newly established proteomic approaches and genetic mouse models to examine the contribution of alternative renal peptidases to ACE2-independent formation of ANG-(1–7). In situ and in vitro mass...

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Bibliographic Details
Main Authors: Grobe, Nadja, Weir, Nathan M., Leiva, Orly, Ong, Frank S., Bernstein, Kenneth E., Schmaier, Alvin H., Morris, Mariana, Elased, Khalid M.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651643/
https://ncbi.nlm.nih.gov/pubmed/23392115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00346.2012
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