Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron of C9orf72 was found to be a common cause of both illnesses; however, the molecular pathogenesis of this expanded repeat is unkn...

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Detalhes bibliográficos
Main Authors: Xu, Zihui, Poidevin, Mickael, Li, Xuekun, Li, Yujing, Shu, Liqi, Nelson, David L., Li, He, Hales, Chadwick M., Gearing, Marla, Wingo, Thomas S., Jin, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651485/
https://ncbi.nlm.nih.gov/pubmed/23553836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219643110
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