Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions

Purpose: Biological effect of radiation can be enhanced with hypofractionation, localized dose escalation, and, in particle therapy, with optimized distribution of linear energy transfer (LET). The authors describe a method to construct inhomogeneous fractional dose (IFD) distributions, and evaluate...

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Bibliographic Details
Main Authors: Zeng, Chuan, Giantsoudi, Drosoula, Grassberger, Clemens, Goldberg, Saveli, Niemierko, Andrzej, Paganetti, Harald, Efstathiou, Jason A., Trofimov, Alexei
Format: Artigo
Language:Inglês
Published: American Association of Physicists in Medicine 2013
Subjects:
Radiation Therapy Physics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651218/
https://ncbi.nlm.nih.gov/pubmed/23635256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1118/1.4801897
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