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MSK2 negatively regulates p53 activity in the absence of stress

Mitogen- and stress-activated kinase 2 (MSK2) is an inhibitor of the transcription factor p53; here, we investigate the mechanisms underlying this inhibition. In the absence of stress stimuli, MSK2 selectively suppressed the expression of a subset of p53 target genes. This basal inhibition of p53 by...

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書誌詳細
主要な著者: Llanos, Susana, Cuadrado, Ana, Serrano, Manuel
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650460/
https://ncbi.nlm.nih.gov/pubmed/19797274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000205
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