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Structural Basis for Treating Tumor Necrosis Factor α (TNFα)-associated Diseases with the Therapeutic Antibody Infliximab

Monoclonal antibody (mAb) drugs have been widely used for treating tumor necrosis factor α (TNFα)-related diseases for over 10 years. Although their action has been hypothesized to depend in part on their ability to bind precursor cell surface TNFα, the precise mechanism and the epitope bound on TNF...

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Bibliografiske detaljer
Main Authors: Liang, Shuaiyi, Dai, Jianxin, Hou, Sheng, Su, Lishu, Zhang, Dapeng, Guo, Huaizu, Hu, Shi, Wang, Hao, Rao, Zihe, Guo, Yajun, Lou, Zhiyong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650416/
https://ncbi.nlm.nih.gov/pubmed/23504311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433961
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