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Aristaless-Related Homeobox Plays a Key Role in Hyperplasia of the Pancreas Islet α–Like Cells in Mice Deficient in Proglucagon-Derived Peptides
Defects in glucagon action can cause hyperplasia of islet α-cells, however, the underlying mechanisms remain largely to be elucidated. Mice homozygous for a glucagon-GFP knock-in allele (Gcg(gfp/gfp)) completely lack proglucagon-derived peptides and exhibit hyperplasia of GFP-positive α-like cells....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650067/ https://ncbi.nlm.nih.gov/pubmed/23671715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064415 |
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