Contribution of V(H) replacement products to the generation of anti-HIV antibodies

V(H) replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes and diversify antibody repertoire. The biological significance of V(H) replacement remains to be explored. Here, we show that V(H) replacement products are highly enriched in IgH genes encoding anti-HIV...

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Hlavní autoři: Liao, Hongyan, Guo, Jun-tao, Lange, Miles D., Fan, Run, Zemlin, Michael, Su, Kaihong, Guan, Yongjun, Zhang, Zhixin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649862/
https://ncbi.nlm.nih.gov/pubmed/23220404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2012.11.003
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