In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction

The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for their ability to protect the cardiovascular s...

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Main Authors: Boehm, O., Markowski, P., van der Giet, M., Gielen, V., Kokalova, A., Brill, C., Hoeft, A., Baumgarten, G., Meyer, R., Knuefermann, P.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649709/
https://ncbi.nlm.nih.gov/pubmed/23690658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/217297
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