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Disruption of Endothelial Peroxisome Proliferator-activated Receptor γ Accelerates Diet-induced Atherogenesis in Low-density Lipoprotein Receptor-null Mice

OBJECTIVE: Peroxisome proliferator-activated receptor γ (PPARγ) is widely expressed in vessel walls, and its activation by agonists showed beneficial effects in cardiovascular diseases. However, the role of endothelial cell (EC) PPARγ in atherogenesis is not fully understood. METHODS AND RESULTS: To...

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Main Authors: Qu, Aijuan, Shah, Yatrik M., Manna, Soumen K., Gonzalez, Frank J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649072/
https://ncbi.nlm.nih.gov/pubmed/22015658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.239137
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