Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

The cyclooxygenase (COX) product, prostacyclin (PGI(2)), inhibits platelet activation and vascular smooth-muscle cell migration and proliferation. Biochemically selective inhibition of COX-2 reduces PGI(2) biosynthesis substantially in humans. Because deletion of the PGI(2) receptor accelerates athe...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Praticò, Domenico, Tillmann, Cyrus, Zhang, Zhi-Bing, Li, Hongwei, FitzGerald, Garret A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061607398
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