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Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

The cyclooxygenase (COX) product, prostacyclin (PGI(2)), inhibits platelet activation and vascular smooth-muscle cell migration and proliferation. Biochemically selective inhibition of COX-2 reduces PGI(2) biosynthesis substantially in humans. Because deletion of the PGI(2) receptor accelerates athe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Praticò, Domenico, Tillmann, Cyrus, Zhang, Zhi-Bing, Li, Hongwei, FitzGerald, Garret A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30658/
https://ncbi.nlm.nih.gov/pubmed/11248083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061607398
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