Conformational Epitope Consisting of the V3 and V4 Loops as a Target for Potent and Broad Neutralization of Simian Immunodeficiency Viruses

Inducing neutralizing antibodies (NAb) is the key to developing a protective vaccine against human immunodeficiency virus type 1 (HIV-1). To clarify the neutralization mechanism of simian immunodeficiency virus (SIV), we analyzed NAb B404, which showed potent and broad neutralizing activity against...

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Main Authors: Kuwata, Takeo, Takaki, Kaori, Yoshimura, Kazuhisa, Enomoto, Ikumi, Wu, Fan, Ourmanov, Ilnour, Hirsch, Vanessa M., Yokoyama, Masaru, Sato, Hironori, Matsushita, Shuzo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648159/
https://ncbi.nlm.nih.gov/pubmed/23468483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00201-13
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