A Proautophagic Antiviral Role for the Cellular Prion Protein Identified by Infection with a Herpes Simplex Virus 1 ICP34.5 Mutant

The cellular prion protein (PrP) often plays a cytoprotective role by regulating autophagy in response to cell stress. The stress of infection with intracellular pathogens can stimulate autophagy, and autophagic degradation of pathogens can reduce their replication and thus help protect the infected...

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Библиографические подробности
Главные авторы: Korom, Maria, Wylie, Kristine M., Wang, Hong, Davis, Katie L., Sangabathula, Meher S., DeLassus, Gregory S., Morrison, Lynda A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Cellular Response to Infection
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648145/
https://ncbi.nlm.nih.gov/pubmed/23487467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02559-12
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