A Proautophagic Antiviral Role for the Cellular Prion Protein Identified by Infection with a Herpes Simplex Virus 1 ICP34.5 Mutant

The cellular prion protein (PrP) often plays a cytoprotective role by regulating autophagy in response to cell stress. The stress of infection with intracellular pathogens can stimulate autophagy, and autophagic degradation of pathogens can reduce their replication and thus help protect the infected...

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Detalhes bibliográficos
Main Authors: Korom, Maria, Wylie, Kristine M., Wang, Hong, Davis, Katie L., Sangabathula, Meher S., DeLassus, Gregory S., Morrison, Lynda A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648145/
https://ncbi.nlm.nih.gov/pubmed/23487467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02559-12
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