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Human Cytomegalovirus Inhibits Apoptosis by Proteasome-Mediated Degradation of Bax at Endoplasmic Reticulum-Mitochondrion Contacts

Human cytomegalovirus (HCMV) encodes the UL37 exon 1 protein (pUL37x1), which is the potent viral mitochondrion-localized inhibitor of apoptosis (vMIA), to increase survival of infected cells. HCMV vMIA traffics from the endoplasmic reticulum (ER) to ER subdomains, which are physically linked to mit...

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Hlavní autoři: Zhang, Aiping, Hildreth, Richard L., Colberg-Poley, Anamaris M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648137/
https://ncbi.nlm.nih.gov/pubmed/23487455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00145-13
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