Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome following Infection with Entamoeba histolytica

Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hypot...

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Autors principals: Mackey-Lawrence, Nicole M., Guo, Xiaoti, Sturdevant, Daniel E., Virtaneva, Kimmo, Hernandez, Matthew M., Houpt, Eric, Sher, Alan, Porcella, Stephen F., Petri, William A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647980/
https://ncbi.nlm.nih.gov/pubmed/23429533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01383-12
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