Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ

This review compares two novel polygenic mouse models of type 2 diabetes (T2D), TALLYHO/JngJ and NONcNZO10/LtJ, and contrasts both with the well-known C57BLKS/J-Lepr(db) (db/db) monogenic diabesity model. We posit that the new polygenic models are more representative of the “garden variety” obesity...

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Autors principals: Leiter, Edward H., Strobel, Marjorie, O'Neill, Adam, Schultz, David, Schile, Andrew, Reifsnyder, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Review Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647594/
https://ncbi.nlm.nih.gov/pubmed/23671854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/165327
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