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Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

Autophosphorylation sites of growth factor receptors with tyrosine kinase activity function as specific binding sites for Src homology 2 (SH2) domains of signaling molecules. This interaction appears to be a crucial step in a mechanism by which receptor tyrosine kinases relay signals to downstream s...

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Udgivet i:Mol Cell Biol
Principais autores: Nishimura, R, Li, W, Kashishian, A, Mondino, A, Zhou, M, Cooper, J, Schlessinger, J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364751/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7692233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.11.6889-6896.1993
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