The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein.

The oncogene mdm2 has been found to be amplified in human sarcomas, and the gene product binds to the tumor suppressor p53. In this report, we describe the dissection of the MDM2-binding domain on p53 as well as the p53-binding domain on MDM2. We also demonstrate that the oncoprotein simian virus 40...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Brown, D R, Deb, S, Muñoz, R M, Subler, M A, Deb, S P
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.11.6849-6857.1993
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