The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein.

The oncogene mdm2 has been found to be amplified in human sarcomas, and the gene product binds to the tumor suppressor p53. In this report, we describe the dissection of the MDM2-binding domain on p53 as well as the p53-binding domain on MDM2. We also demonstrate that the oncoprotein simian virus 40...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Brown, D R, Deb, S, Muñoz, R M, Subler, M A, Deb, S P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.11.6849-6857.1993
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