Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

Raf-1 is a serine/threonine kinase which is essential in cell growth and differentiation. Tyrosine kinase oncogenes and receptors and p21ras can activate Raf-1, and recent studies have suggested that Raf-1 functions upstream of MEK (MAP/ERK kinase), which phosphorylates and activates ERK. To determi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Macdonald, S G, Crews, C M, Wu, L, Driller, J, Clark, R, Erikson, R L, McCormick, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364724/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.11.6615-6620.1993
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