Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

Raf-1 is a serine/threonine kinase which is essential in cell growth and differentiation. Tyrosine kinase oncogenes and receptors and p21ras can activate Raf-1, and recent studies have suggested that Raf-1 functions upstream of MEK (MAP/ERK kinase), which phosphorylates and activates ERK. To determi...

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Detalhes bibliográficos
Main Authors: Macdonald, S G, Crews, C M, Wu, L, Driller, J, Clark, R, Erikson, R L, McCormick, F
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC364724/
https://ncbi.nlm.nih.gov/pubmed/8413257
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