Cationic Cell-Penetrating Peptide Binds to Planar Lipid Bilayers Containing Negatively Charged Lipids but does not Induce Conductive Pores

Using a cation-selective gramicidin A channel as a sensor of the membrane surface charge, we studied interactions of oligoarginine peptide R9C, a prototype cationic cell-penetrating peptide (CPP), with planar lipid membranes. We have found that R9C sorption to the membrane depends strongly on its li...

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Detalhes bibliográficos
Main Authors: Gurnev, Philip A., Yang, Sung-Tae, Melikov, Kamran C., Chernomordik, Leonid V., Bezrukov, Sergey M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Membrane
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647162/
https://ncbi.nlm.nih.gov/pubmed/23663836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.02.053
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