A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the Drosophila and human proteins have considerable homology, extending beyond the putative catalytic region to inclu...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Bolger, G, Michaeli, T, Martins, T, St John, T, Steiner, B, Rodgers, L, Riggs, M, Wigler, M, Ferguson, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413254/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.10.6558-6571.1993
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