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The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes

Interleukin-15 (IL-15) is an important IL-2 related cytokine, whose role in Th17 cell biology has not been fully elucidated. Here we show that exogenous IL-15 decreased IL-17A production in Th17 cultures. Neutralizing IL-15 using an antibody led to increases in IL-17A production in Th17 cultures. Bo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pandiyan, Pushpa, Yang, Xiang-Ping, Saravanamuthu, Senthil S, Zheng, Lixin, Ishihara, Satoru, O’Shea, John J., Lenardo, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647038/
https://ncbi.nlm.nih.gov/pubmed/22993203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201476
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