Opposing regulation of the Il17 locus through direct, reciprocal actions of STAT3 and STAT5

IL-2, a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of STAT3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and RORγt and inhibits FOXP3, IL-2 inhibited IL-17 independently...

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Bibliografiske detaljer
Main Authors: Yang, Xiang-Ping, Ghoreschi, Kamran, Steward-Tharp, Scott M., Rodriguez-Canales, Jaime, Zhu, Jinfang, Grainger, John R., Hirahara, Kiyoshi, Sun, Hong-Wei, Wei, Lai, Vahedi, Golnaz, Kanno, Yuka, O’Shea, John J., Laurence, Arian
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182404/
https://ncbi.nlm.nih.gov/pubmed/21278738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1995
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