Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism

Persistent patency of the ductus arteriosus (PDA) is a common problem in preterm infants. The antacid cimetidine is a potent antagonist of the H2 histamine receptor but also inhibits certain cytochrome P450 enzymes (CYPs), which may affect DA patency. We examined whether cimetidine contributes to PD...

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Main Authors: Cotton, Robert B., Shah, Lisa P., Poole, Stanley D., Ehinger, Noah J., Brown, Naoko, Shelton, Elaine L., Slaughter, James C., Baldwin, H. Scott, Paria, Bibhash C., Reese, Jeff
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646934/
https://ncbi.nlm.nih.gov/pubmed/23454087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.02.010
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