Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. We demonstrate that AML-1 is a DNA-binding protein which sp...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Meyers, S, Downing, J R, Hiebert, S W
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364692/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413232/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.10.6336
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