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mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats

Glutamate NMDA receptors mediate many molecular and behavioral effects of alcohol, and they play a key role in the development of excessive drinking. Uncompetitive NMDA receptor antagonists may, therefore, have therapeutic potential for alcoholism. The first aim was to compare the effects of the NMD...

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Detalhes bibliográficos
Main Authors: Sabino, Valentina, Narayan, Aditi R., Zeric, Tamara, Steardo, Luca, Cottone, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646912/
https://ncbi.nlm.nih.gov/pubmed/23466691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2013.02.030
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