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B-Raf and the inhibitors: from bench to bedside

The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers. An important V600E mutation has been identified and can cause constitutive B-Raf activation. Recent studies have evaluat...

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Detalhes bibliográficos
Main Authors: Huang, Tiangui, Karsy, Michael, Zhuge, Jian, Zhong, Minghao, Liu, Delong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646677/
https://ncbi.nlm.nih.gov/pubmed/23617957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-30
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