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MEK and the inhibitors: from bench to bedside

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Akinleye, Akintunde, Furqan, Muhammad, Mukhi, Nikhil, Ravella, Pavan, Liu, Delong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626705/
https://ncbi.nlm.nih.gov/pubmed/23587417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-27
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