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MEK and the inhibitors: from bench to bedside

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutati...

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Main Authors: Akinleye, Akintunde, Furqan, Muhammad, Mukhi, Nikhil, Ravella, Pavan, Liu, Delong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626705/
https://ncbi.nlm.nih.gov/pubmed/23587417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-27
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