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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Rapamycin is a macrolide antifungal agent that exhibits potent immunosuppressive properties. In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic receptor which is a homolog of human FKBP12 (hFKBP12). Deletion of the gene for yeast FKBP12 (RBP1) results in recessi...

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Udgivet i:Mol Cell Biol
Principais autores: Cafferkey, R, Young, P R, McLaughlin, M M, Bergsma, D J, Koltin, Y, Sathe, G M, Faucette, L, Eng, W K, Johnson, R K, Livi, G P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364661/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.10.6012-6023.1993
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