Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Rapamycin is a macrolide antifungal agent that exhibits potent immunosuppressive properties. In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic receptor which is a homolog of human FKBP12 (hFKBP12). Deletion of the gene for yeast FKBP12 (RBP1) results in recessi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Cafferkey, R, Young, P R, McLaughlin, M M, Bergsma, D J, Koltin, Y, Sathe, G M, Faucette, L, Eng, W K, Johnson, R K, Livi, G P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8413204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.10.6012-6023.1993
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