Attenuating homologous recombination stimulates an AID-induced antileukemic effect

Activation-induced cytidine deaminase (AID) is critical in normal B cells to initiate somatic hypermutation and immunoglobulin class switch recombination. Accumulating evidence suggests that AID is also prooncogenic, inducing cancer-promoting mutations or chromosome rearrangements. In this context,...

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Detalhes bibliográficos
Main Authors: Lamont, Kristin R., Hasham, Muneer G., Donghia, Nina M., Branca, Jane, Chavaree, Margaret, Chase, Betsy, Breggia, Anne, Hedlund, Jacquelyn, Emery, Ivette, Cavallo, Francesca, Jasin, Maria, Rüter, Jens, Mills, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646491/
https://ncbi.nlm.nih.gov/pubmed/23589568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121258
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