Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity

Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared to WT mice. CR applied to AC5 KO result in rapid decrease in body weight, metabolic deterioration a...

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Main Authors: Yan, Lin, Park, Ji Yeon, Dillinger, Jean-Guillaume, De Lorenzo, Mariana S., Yuan, Chujun, Lai, Lo, Wang, Chunbo, Ho, David, Tian, Bin, Stanley, William C, Auwerx, Johan, Vatner, Dorothy E., Vatner, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646327/
https://ncbi.nlm.nih.gov/pubmed/23020244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12013
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