Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

The 118A>G single nucleotide polymorphism (SNP) in the μ-opioid receptor (OPRM1) gene has been the most described variant in pharmacogenetic studies regarding opioid drugs. Despite evidence for an altered biological function encoded by this variant, this knowledge is not yet utilized clinically....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mura, Elisa, Govoni, Stefano, Racchi, Marco, Carossa, Valeria, Ranzani, Guglielmina Nadia, Allegri, Massimo, van Schaik, Ron HN
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2013
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645947/
https://ncbi.nlm.nih.gov/pubmed/23658496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S42040
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