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Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

Mutations were targeted to the Hprt locus of mouse embryo-derived stem cells by using 22 different sequence replacement and sequence insertion vectors. The targeting frequency was examined at two sites within the Hprt locus as a function of the extent of homology between the targeting vector and the...

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Bibliografiske detaljer
Main Authors: Deng, C, Capecchi, M R
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC364584/
https://ncbi.nlm.nih.gov/pubmed/1321331
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