Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
We demonstrate that the frequency of gene targeting is unaffected by the length of nonhomologous DNA transferred to a target chromosomal sequence. A result of this finding is that a much wider spectrum of designed genomic alterations is now feasible. As a first application, we inserted a 5.4-kilobas...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1990
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2120706/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7688 |
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