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Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central mediators of cardiac hypertrophy and are discussed as potential therapeutic targets. However, direct inhibition of ERK1/2 leads to exacerbated cardiomyocyte death and impaired heart function. We have previously identified ERK(Thr188...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645583/ https://ncbi.nlm.nih.gov/pubmed/23589880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221999110 |
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