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How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency

Mathematical optimization framework allows the identification of certain nodes within a signaling network. In this work, we analyzed the complex extracellular-signal-regulated kinase 1 and 2 (ERK1/2) cascade in cardiomyocytes using the framework to find efficient adjustment screws for this cascade t...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Breitenbach, Tim, Lorenz, Kristina, Dandekar, Thomas
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539830/
https://ncbi.nlm.nih.gov/pubmed/31052520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092179
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