Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis. We identify a Spliceosome-Coupled And Nuclear RNAi (SCANR) complex required for siRN...

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Hauptverfasser: Dumesic, Phillip A., Natarajan, Prashanthi, Chen, Changbin, Drinnenberg, Ines A., Schiller, Benjamin J., Thompson, James, Moresco, James J., Yates, John R., Bartel, David P., Madhani, Hiten D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645481/
https://ncbi.nlm.nih.gov/pubmed/23415457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.046
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