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Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells
To provide a lifelong supply of blood cells, hematopoietic stem cells (HSCs) need to carefully balance both self-renewing cell divisions and quiescence. Although several regulators that control this mechanism have been identified, we demonstrate that the transcription factor PU.1 acts upstream of th...
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Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , , , |
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Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
2013
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3644723/ https://ncbi.nlm.nih.gov/pubmed/23395001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.007 |
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