Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

To provide a lifelong supply of blood cells, hematopoietic stem cells (HSCs) need to carefully balance both self-renewing cell divisions and quiescence. Although several regulators that control this mechanism have been identified, we demonstrate that the transcription factor PU.1 acts upstream of th...

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Main Authors: Staber, Philipp B., Zhang, Pu, Ye, Min, Welner, Robert S., Nombela-Arrieta, César, Bach, Christian, Kerenyi, Marc, Bartholdy, Boris A., Zhang, Hong, Alberich-Jordà, Meritxell, Lee, Sanghoon, Yang, Henry, Ng, Felicia, Zhang, Junyan, Leddin, Mathias, Silberstein, Leslie E., Hoefler, Gerald, Orkin, Stuart H., Göttgens, Berthold, Rosenbauer, Frank, Huang, Gang, Tenen, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644723/
https://ncbi.nlm.nih.gov/pubmed/23395001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.007
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